Tests for Evaluation of Bio - Compatiability

The material should pass all the three levels of bio-compatibility testing before it is approved for final usage in the human oral cavity. The three levels are as follows:

Primary tests:

Cytotoxicity tests
Genotoxicity tests.

Secondary tests:

Systemic toxicity testing
Inhalation toxicity testing
Skin irritation and sensitization tests
Implantation tests.

Preclinical usage tests:

Pulp and dentin usage tests
Pulp capping and pulpotomy usage tests
Endodontic usage tests.

Let us learn more about these tests.